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Sterols: Anti-inflammation and Anti-tumor

Introduction: Professors from College of Science and Technology, Nihon University pointed out in Chemistry & Biodiversity that triterpene acids and sterols from Ganoderma lucidum have the effects of anti-inflammation and anti-tumor.

References: Akihisa T, Nakamura Y, Tagata M, Tokuda H, et al.Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum.Chem Biodivers. 2007 Feb; 4(2):224-31

Sterols: Anti-cancer

Introduction: Universities in China jointly found that sterols has the effect of suppressing cancer growth.

References: Cui Jianguo, Zeng Longmei, Su Jingyu, Peng Wenlie, Xu Anlong. Synthesis of Some Polyhydroxysterols and Investigation of Relationship Between Their Structure and Cytotoxicity
[J] .Chemical Journal of Chinese Universities, 2000 (09): 1399-1404

Sterols: Overcoming drug resistance of tumor cells

Introduction: State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology pointed out in Plos ONE (2010) that ergosterol peroxide is more active in inducing miR-378 cell death than inducing GFP cell death. Compared to control group cells, ergosterol peroxide with lower concentration is required to induce the death of miR-378 transfected cells. With further clinical development, ergosterol peroxide represents a promising new agent that can overcome the drug resistance of tumor cells.

References: PLOS ONE (eISSN-1932-6203) is an international, peer-reviewed, open-access, online publication.


IntroductionZhejiang University, Chiba University and Sichuan Agricultural University jointly stated in Bioscience, Biotechnology, and Biochemistry (2009) that sterols play an important role in anti-aging.

ReferenceYufang Weng,Lan Xiang,Akira Matsuura,Yang Zhang, Qianming Huang,Jianhua Qi. Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene[J]. Bioorganic & Medicinal Chemistry, 2009,18(3).