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Sep 02, 2022


How many health benefits does "Reishi extract + sporoderm-broken spore powder" have? The following three studies provide the effects we have known for over a decade.

Part one of the trilogy: Protect the liver and reduce chemical liver damage

The "Research on the Protective Effect of whole Ganoderma lucidum spore Powder on Chemical Liver Injury" published in Practical Preventive Medicine in 2007 proved that "Ganoderma lucidum extract + sporoderm-broken spore powder" has a good hepatoprotective effect through animal experiments.

According to the research report, the whole Ganoderma lucidum spore powder is a combination of "Ganoderma lucidum extract + sporoderm-broken spore powder":

Ganoderma lucidum is extracted twice with alcohol and then extracted with water, and the intermediate extract produced by this method is mixed, concentrated and spray-dried to obtain Ganoderma lucidum extract powder. Then, the Ganoderma lucidum spore powder is mixed with the Ganoderma lucidum extract powder in appropriate proportion after sporoderm-breaking treatment, and further dried and sterilized to obtain the whole Ganoderma lucidum spore powder with its polysaccharide content of above 10% and its triterpenoid content of above 8%.”

The researchers fed healthy experimental mice with whole Ganoderma lucidum spore powder every day for 30 days, and administered a chemical toxic substance CCl4 (carbon tetrachloride) to the mice by gavage to induce acute liver injury on the 30th day.

CCl4 will quickly damage liver cells, causing ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in liver cells to penetrate into the blood. Therefore, the severity of liver damage can be known according to these two liver indexes in the blood combined with histopathological analysis.

The results are shown in the figure below:

The levels of both ALT and AST increased substantially in mice without the protection of the whole Ganoderma lucidum spore powder while the levels of ALT and AST were significantly lower in mice that previously ate the whole Ganoderma lucidum spore powder every day.


The results of liver histopathology are also consistent with liver indicators: the severity and range of cell necrosis and cytopathic effects such as cell edema, cell inflammation and swelling and steatosis caused by CCl4 destruction in liver tissue of the mice consuming whole Ganoderma lucidum spore powder every day are reduced by more than half.

CCl4 can directly damage the liver severely, so it is often used to evaluate the hepatoprotective effect. Obviously, daily consumption of “Ganoderma lucidum extract + sporoderm-broken spore powder” should be able to significantly reduce various chemical liver damage that may be caused by diet and drugs. 

Part two of the trilogy: Protect bone marrow and white blood cells and alleviate radiation damage

The "Research on the protective effect of compound Ganoderma lucidum powder on radiation-injured mice" published in "Central South Pharmacy" in 2007 proved that "Ganoderma lucidum extract + sporoderm-broken spore powder" can reduce bone marrow cell damage, leukopenia and immunocompromise caused by radiotherapy.

According to the research report, "Compound Ganoderma lucidum preparation is a powder prepared from the extract powder (1g of extract powder is equivalent to 20g of Ganoderma lucidum fruiting body) made from Ganoderma lucidum extract through concentration and spray drying process and the sporoderm-broken Ganoderma lucidum spore powder in an appropriate proportion.". It is understood that the compound Ganoderma lucidum preparation made of "Ganoderma lucidum extract + sporoderm-broken spore powder" is the same as the "whole Ganoderma lucidum spore powder" used in the previous study on liver protection.

The researchers first fed the experimental mice a compound Ganoderma lucidum preparation for 14 days, and then irradiated them with Cobalt-60, a source of radiation commonly used in the treatment of cancer, and evaluated them 3 and 14 days after irradiation.

It was found that the recovery of white blood cells, the DNA content of the overall bone marrow cells, and the level of serum hemolysin, which represents the level of immune function, in these mice were much better than those in mice that were directly irradiated with Cobalt-60 without the protection of compound Ganoderma lucidum preparations (as shown in the figure below).


Apparently, the compound Ganoderma lucidum preparation provided considerable protection for the mice either by making the cells more resistant to radiation damage or by enhancing their resilience and speed of recovery.

The type of radiation used to treat cancer, known as gamma rays, is one of the most lethal types of radiation. Radiation is the electromagnetic wave emitted from an object. Infrared radiation, ultraviolet radiation, microwaves, X-rays, electromagnetic waves generated by electrical equipment and nuclear energy radiation are all radiations that people are more or less worried about.

It can be seen that patients receiving radiotherapy need "Ganoderma lucidum extract + sporoderm-broken spore powder" to reduce radiation damage, and we can also rely on "Ganoderma lucidum extract + sporoderm-broken wall spore powder" to mitigate the damage caused by radiations that cannot be avoided in daily life.

Part three of the trilogy: Help immune drugs fight cancer 

In theory, liver protection and anti-radiation should be two different effects, but both can be achieved by "Ganoderma lucidum extract + sporoderm-broken spore powder" from the same source.

As for how "Ganoderma lucidum extract + sporoderm-broken spore powder" assists immune drugs to fight cancer? Stay tuned for Part three of the trilogy (to be continued).


1) Zongxiu Huang et al., Research on the protective effect of whole Ganoderma lucidum spore powder on chemical liver injury. Practical Preventive Medicine, 2007, 14(3): 897-898.

2) Zongxiu Huang et al., Research on the protective effect of compound Ganoderma lucidum powder on radiation-injured mice. Central South Pharmacy, 2007, 5(1): 26-28.



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★ The original text of this article was written in Chinese by Wu Tingyao and translated into English by Alfred Liu. If there is any discrepancy between the translation (English) and the original (Chinese), the original Chinese shall prevail. If readers have any questions, please contact the original author, Ms. Wu Tingyao.